Soil acidity has become a serious threat to crop production in most highlands of Ethiopia in general and in the western part of the country in particular. Furthermore, technical information with regard to the role of liming and its interaction effect with coffee husk compost for soil acidity amelioration is scarce in Anfilo areas for crop production in general and coffee in particular. A field experiment was conducted to assess the effects of lime, coffee husk compost, NP fertilizer and their combinations on growth response and yield of coffee (Coffea arabica L.) at Mugi Agricultural Research Sub-Center in Anfilo district, Western Ethiopia. The treatments consisted of ten combinations of different rates of coffee husk compost, lime and NP fertilizers, and laid out in randomized complete block design with three replications. Soil samples were taken and analyzed for selected physicochemical properties following the standard laboratory procedures. All relevant coffee growth parameters and yield data were collected and subjected to Analysis of Variance using SAS package and treatment means were compared at 0.05 probability level using least significant difference test. The results revealed that integrated application of coffee husk compost and lime with NP fertilizer significantly increased growth parameters and yield of coffee. The highest growth performance of coffee (plant height, number of primary branch and stem girth) and highest yield of coffee (1928.08kgha^-1) were recorded from the integrated use of 50% recommended coffee husk compost and lime with NP fertilizer (5 t ha^-1 coffee husk compost + 1.1 t ha^-1 lime + 86 kg ha^-1 N and 38 kg ha^-1P fertilizer). From the study, it can be concluded that integrated application of 5 t ha^-1 coffee husk compost and 1.1 t ha^-1 lime with 86 kg ha^-1 N and 38 kg ha^-1P fertilizer to acidic soil could be a promising alternative amendment for acid soil management and sustainable coffee production in Anfilo district, western Ethiopia.